Understanding the Research
The Science Behind the OxyPeak Method
What the Research Tells Us
Not all scientists use the same hyperbaric oxygen therapy (HBOT) protocol while conducting their research and clinical testing.
The studies featured below were selected because they explore HBOT protocols using oxygen fluctuation techniques similar in principle to the OxyPeak Method.
The research presented on this page is provided for educational purposes only. Many of the studies listed involve applications of hyperbaric oxygen therapy (HBOT) that are not currently FDA-approved indications. These studies include randomized controlled trials, retrospective studies, case reports and other peer-reviewed research. Study titles reflect the original authors’ framing, and research findings do not represent guaranteed outcomes.
Treatment decisions should always be made in consultation with a qualified healthcare professional.
Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial
Aging (2021)
Cognitive enhancement of older adults using hyperbaric oxygen: a randomized controlled trial
Neural Regeneration Research (2018)
How we age isn’t determined by a single factor. These studies look at physical function, cognitive performance, cellular health, and longevity.
BMC Geriatrics (2024)
Frontiers in Neurology (2022)
Biomolecules (2021)
Aging (2021)
Aging (2020)
The effects of a concussion or traumatic brain injury can sometimes linger long after the initial injury. These studies look at brain function, cognitive performance, recovery, and quality of life.
Frontiers in Neurology (2025)
Expert Review of Neurotherapeutics (2025)
Scientific Reports (2022)
BMJ Open (2018)
Frontiers in Human Neuroscience (2017)
Restorative Neurology and Neuroscience (2015)
Post-traumatic stress can influence sleep, concentration, mood, relationships, and overall quality of life. These studies explore the role of oxygen in Veterans and others living with the long-term effects of psychological trauma.
Brain and Behavior (2025)
Journal of Clinical Psychiatry (2024)
Annals of Case Reports (2024)
Frontiers in Neuroscience (2023)
Military Medicine (2022)
Long COVID can look different from one person to the next. These studies explore several of the more common symptoms.
Scientific Reports (2024)
Scientific Reports (2023)
NeuroImage: Clinical (2022)
Scientific Reports (2022)
International Journal of Physical Medicine & Rehabilitation (2022)
The brain’s ability to heal and adapt can continue after a stroke or neurological injury. These studies examine recovery, neuroplasticity, memory, movement, and other aspects of neurological function.
Frontiers in Neurology (2023)
Restorative Neurology and Neuroscience (2015)
Restorative Neurology and Neuroscience (2020)
Neuropsychology (2015)
Not all research focuses on illness or disease. Some researchers have explored how oxygen may influence exercise capacity, recovery, endurance, and physical performance in healthy adults.
Living with chronic pain can affect nearly every aspect of life. These studies explore how oxygen may affect people living with fibromyalgia and other chronic pain-related conditions.
Journal of Medical Case Reports (2025)
Clinical and Experimental Rheumatology (2019)
Frontiers in Psychology (2018)
Frontiers in Psychology (2018)
Frontiers in Psychology (2018)
Scientific Reports (2023)
International Journal of Cardiovascular Imaging (2020)
Aging Male (2019)
International Journal of Impotence Research (2018)
We are often asked “Is HBOT safe?” These studies examine treatment safety, side effects, and other factors that help physicians evaluate and manage patient care.
PLOS ONE (2025)
BMC Pulmonary Medicine (2019)
Undersea and Hyperbaric Medicine (2016)
Undersea and Hyperbaric Medicine (2016)
Researchers continue to explore hyperbaric oxygen therapy in a variety of medical settings. These publications highlight several additional areas of investigation that don’t fit neatly into the categories above.
Intensive and Critical Care Nursing (2018)
Undersea and Hyperbaric Medicine (2018)
Plastic and Reconstructive Surgery Global Open (2019)
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