Understanding the Research
The Science Behind the OxyPeak Method
What the Research Tells Us
Not all scientists use the same hyperbaric oxygen therapy (HBOT) protocol while conducting their research and clinical testing.
The studies featured below were selected because they explore HBOT protocols using oxygen fluctuation techniques similar in principle to the OxyPeak Method.
The research presented on this page is provided for educational purposes only. Many of the studies listed involve applications of hyperbaric oxygen therapy (HBOT) that are not currently FDA-approved indications. These studies include randomized controlled trials, retrospective studies, case reports and other peer-reviewed research. Study titles reflect the original authors’ framing, and research findings do not represent guaranteed outcomes.
Treatment decisions should always be made in consultation with a qualified healthcare professional.
Brain Health & Cognitive Performance
The studies below explore how oxygen may influence brain health, cognition, and the brain’s ability to adapt and change over time.
Frontiers in Neurology (2024)
Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial
Aging (2021)
Cognitive enhancement of older adults using hyperbaric oxygen: a randomized controlled trial
Aging (2020)
Hyperbaric Oxygen Therapy as a New Approach for Alzheimer’s Disease
Neural Regeneration Research (2018)
Neural Regeneration Research (2018)
Healthy Aging and Longevity
How we age isn’t determined by a single factor. These studies look at physical function, cognitive performance, cellular health, and longevity.
Physical enhancement of older adults using hyperbaric oxygen: a randomized controlled trial
BMC Geriatrics (2024)
BMC Geriatrics (2024)
The effect of hyperbaric oxygen therapy on cognition, performance, proteomics, and telomere length: The difference between zero and one
Frontiers in Neurology (2022)
Frontiers in Neurology (2022)
Hyperbaric Oxygen Treatment: Effects on Mitochondrial Function and Oxidative Stress
Biomolecules (2021)
Biomolecules (2021)
The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial
Aging (2021)
Aging (2021)
Cognitive enhancement of older adults using hyperbaric oxygen: a randomized controlled trial
Aging (2020)
Aging (2020)
Traumatic Brain Injury and Post-Concussion Syndrome
The effects of a concussion or traumatic brain injury can sometimes linger long after the initial injury. These studies look at brain function, cognitive performance, recovery, and quality of life.
Hyperbaric oxygen therapy improves post-concussion symptoms in adults with childhood traumatic brain injury: a retrospective cohort study
Frontiers in Neurology (2025)
Frontiers in Neurology (2025)
Persistent post-concussion syndrome: pathophysiology, diagnosis, current and evolving treatment strategies
Expert Review of Neurotherapeutics (2025)
Expert Review of Neurotherapeutics (2025)
Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial
Scientific Reports (2022)
Scientific Reports (2022)
Effect of Hyperbaric Oxygen Therapy on Chronic Neurocognitive Deficits of Post-Traumatic Brain Injury Patients: Retrospective Analysis
BMJ Open (2018)
BMJ Open (2018)
Hyperbaric Oxygen Therapy Can Induce Angiogenesis and Regeneration of Nerve Fibers in Traumatic Brain Injury Patients
Frontiers in Human Neuroscience (2017)
Frontiers in Human Neuroscience (2017)
Hyperbaric Oxygen May Induce Angiogenesis in Patients Suffering from Prolonged Post-Concussion Syndrome Due to Traumatic Brain Injury
Restorative Neurology and Neuroscience (2015)
Restorative Neurology and Neuroscience (2015)
PTSD & Psychological Recovery
Post-traumatic stress can influence sleep, concentration, mood, relationships, and overall quality of life. These studies explore the role of oxygen in Veterans and others living with the long-term effects of psychological trauma.
Hyperbaric Oxygen Therapy for PTSD: Threshold Effect for Sustained Symptom Improvement in a Biologically Based Treatment
Brain and Behavior (2025)
Brain and Behavior (2025)
Hyperbaric Oxygen Therapy for Veterans With Combat-Associated Posttraumatic Stress Disorder: A Randomized, Sham-Controlled Clinical Trial
Journal of Clinical Psychiatry (2024)
Journal of Clinical Psychiatry (2024)
Hyperbaric Oxygen Therapy for Military Post-Traumatic Stress Disorder in Elderly Veterans: Case Studies, Literature Review, and Discussion
Annals of Case Reports (2024)
Annals of Case Reports (2024)
The Use of Hyperbaric Oxygen for Veterans With PTSD: Basic Physiology and Current Available Clinical Data
Frontiers in Neuroscience (2023)
Frontiers in Neuroscience (2023)
Hyperbaric Oxygen Therapy for Veterans With Treatment-Resistant PTSD: A Longitudinal Follow-up Study
Military Medicine (2022)
Military Medicine (2022)
Long COVID
Long COVID can look different from one person to the next. These studies explore several of the more common symptoms.
Long-Term Outcomes of Hyperbaric Oxygen Therapy in Post-COVID Condition: Longitudinal Follow-Up of a Randomized Controlled Trial
Scientific Reports (2024)
Scientific Reports (2024)
The Effect of Hyperbaric Oxygen Therapy on Myocardial Function in Post-COVID-19 Syndrome Patients: A Randomized Controlled Trial
Scientific Reports (2023)
Scientific Reports (2023)
Effects of Hyperbaric Oxygen Therapy on Functional and Structural Connectivity in Post-COVID-19 Condition Patients: A Randomized, Sham-Controlled Trial
NeuroImage: Clinical (2022)
NeuroImage: Clinical (2022)
Hyperbaric Oxygen Therapy Improves Neurocognitive Functions and Symptoms of Post-COVID Condition: Randomized Controlled Trial
Scientific Reports (2022)
Scientific Reports (2022)
Hyperbaric Oxygen Therapy for COVID-19 Patients: A Prospective, Randomized Controlled Trial
International Journal of Physical Medicine & Rehabilitation (2022)
International Journal of Physical Medicine & Rehabilitation (2022)
Stroke & Neurological Recovery
The brain’s ability to heal and adapt can continue after a stroke or neurological injury. These studies examine recovery, neuroplasticity, memory, movement, and other aspects of neurological function.
Functional MRI Evaluation of Hyperbaric Oxygen Therapy Effect on Hand Motor Recovery in a Chronic Post-Stroke Patient: A Case Report and Physiological Discussion
Frontiers in Neurology (2023)
Frontiers in Neurology (2023)
Hyperbaric Oxygen Can Induce Neuroplasticity and Improve Cognitive Functions of Patients Suffering From Anoxic Brain Damage
Restorative Neurology and Neuroscience (2015)
Restorative Neurology and Neuroscience (2015)
Hyperbaric Oxygen Therapy Improves Neurocognitive Functions of Post-Stroke Patients – A Retrospective Analysis
Restorative Neurology and Neuroscience (2020)
Restorative Neurology and Neuroscience (2020)
Improvement of Memory Impairments in Post Stroke Patients by Hyperbaric Oxygen Therapy
Neuropsychology (2015)
Neuropsychology (2015)
Physical Performance
Not all research focuses on illness or disease. Some researchers have explored how oxygen may influence exercise capacity, recovery, endurance, and physical performance in healthy adults.
Fibromyalgia & Chronic Pain
Living with chronic pain can affect nearly every aspect of life. These studies explore how oxygen may affect people living with fibromyalgia and other chronic pain-related conditions.
Efficacy of Hyperbaric Oxygen Therapy in Treating Fibromyalgia Linked to Childhood Trauma After Late-Onset and Over a Decade of Symptoms: A Case Report
Journal of Medical Case Reports (2025)
Journal of Medical Case Reports (2025)
Hyperbaric Oxygen Treatment of Fibromyalgia: A Prospective Observational Clinical Study
Clinical and Experimental Rheumatology (2019)
Clinical and Experimental Rheumatology (2019)
Recovery of Repressed Memories in Fibromyalgia Patients Treated With Hyperbaric Oxygen: Case Series Presentation and Suggested Bio-Psycho-Social Mechanism
Frontiers in Psychology (2018)
Frontiers in Psychology (2018)
Hyperbaric Oxygen Therapy Can Induce Neuroplasticity and Significant Clinical Improvement in Patients Suffering From Fibromyalgia With a History of Childhood Sexual Abuse
Frontiers in Psychology (2018)
Frontiers in Psychology (2018)
Brain and Mind Integration: Childhood Sexual Abuse Survivors Experiencing Hyperbaric Oxygen Treatment and Psychotherapy Concurrently
Frontiers in Psychology (2018)
Frontiers in Psychology (2018)
Heart Function & Vascular Health
The effects of oxygen may extend to areas related to heart function, circulation, vascular health, and erectile dysfunction.
The Effect of Hyperbaric Oxygen Therapy on Myocardial Function in Post-COVID-19 Syndrome Patients: A Randomized Controlled Trial
Scientific Reports (2023)
Scientific Reports (2023)
The Effect of Hyperbaric Oxygenation Therapy on Myocardial Function
International Journal of Cardiovascular Imaging (2020)
International Journal of Cardiovascular Imaging (2020)
The Impact of Hyperbaric Oxygen Therapy on Erectile Functions and Serum Testosterone Levels in Patients With Erectile Dysfunction
Aging Male (2019)
Aging Male (2019)
Hyperbaric Oxygen Can Induce Angiogenesis and Recover Erectile Function
International Journal of Impotence Research (2018)
International Journal of Impotence Research (2018)
Safety & Clinical Practice
We are often asked “Is HBOT safe?” These studies examine treatment safety, side effects, and other factors that help physicians evaluate and manage patient care.
Safety of Hyperbaric Oxygen Therapy in Non-Emergent Patients With a History of Seizures: A Retrospective Cohort Study
PLOS ONE (2025)
PLOS ONE (2025)
Hyperbaric Oxygen Therapy Effects on Pulmonary Functions: A Prospective Cohort Study
BMC Pulmonary Medicine (2019)
BMC Pulmonary Medicine (2019)
The Safety of Hyperbaric Oxygen Treatment: Retrospective Analysis in 2,334 Patients
Undersea and Hyperbaric Medicine (2016)
Undersea and Hyperbaric Medicine (2016)
Seizures During Hyperbaric Oxygen Therapy: Retrospective Analysis of 62,614 Treatment Sessions
Undersea and Hyperbaric Medicine (2016)
Undersea and Hyperbaric Medicine (2016)
Additional Clinical Applications
Researchers continue to explore hyperbaric oxygen therapy in a variety of medical settings. These publications highlight several additional areas of investigation that don’t fit neatly into the categories above.
Carbon Monoxide Poisoning in a Young, Healthy Patient: A Case Study of Heart Failure Recovery After Hyperbaric Oxygenation Treatment
Intensive and Critical Care Nursing (2018)
Intensive and Critical Care Nursing (2018)
Hyperbaric Oxygen for Late Sequelae of Carbon Monoxide Poisoning Enhances Neurological Recovery: Case Report
Undersea and Hyperbaric Medicine (2018)
Undersea and Hyperbaric Medicine (2018)
Hyperbaric Oxygen Preconditioning Can Reduce Postabdominoplasty Complications: A Retrospective Cohort Study
Plastic and Reconstructive Surgery Global Open (2019)
Plastic and Reconstructive Surgery Global Open (2019)
Get In Touch
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